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目的探讨尿液中期因子(MK)与糖尿病肾病的关系。方法 96例糖尿病患者,根据尿白蛋白排泄率分为正常白蛋白尿组(NUA1b组),微量白蛋白尿组(MUA1b组),大量白蛋白尿组(CUA1b组),设对照组(NC组)。用酶联免疫吸附法测定尿液MK水平。结果 CUA1b组尿液MK水平高于NC组、NUA1b组及MUA1b组(P<0.01),MUA1b组高于NC组及NUA1b组(P<0.05),NUA1b组与NC组差异无统计学意义(P>0.05)。相关分析显示,尿液MK与尿白蛋白排泄率(r=0.40,P<0.05)及病程(r=0.23,P<0.05)呈正相关,与内生肌酐清除率(CCr)呈负相关(r=-0.20,P=<0.05)。结论尿液MK可能参与临床糖尿病肾病的发生。
Objective To investigate the relationship between urine midkine (MK) and diabetic nephropathy. Methods Ninety-six diabetic patients were divided into normal albuminuria group (NUA1b group), microalbuminuria group (MUA1b group), large amount of albuminuria group (CUA1b group) and control group (NC group) according to urinary albumin excretion rate ). Urinary MK levels were determined by enzyme-linked immunosorbent assay. Results The urine MK level in CUA1b group was higher than that in NC group, NUA1b group and MUA1b group (P <0.01), MUA1b group was higher than that of NC group and NUA1b group (P <0.05), but there was no significant difference between NUA1b group and NC group > 0.05). Correlation analysis showed that urinary MK was positively correlated with urinary albumin excretion rate (r = 0.40, P <0.05) and course of disease (r = 0.23, P <0.05), and negatively correlated with endogenous creatinine clearance = -0.20, P = <0.05). Conclusion Urinary MK may be involved in the development of clinical diabetic nephropathy.