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以GCLE为原料,通过Witting反应合成7-氨基-3-乙烯-4-头孢烷酸(7-AVCA)。并且结合了酶法裂解,大大缩短了反应时间,产物总收率达到73.2%。
Using GCLE as raw material, 7-amino-3-vinyl-4-cephemic acid (7-AVCA) was synthesized by Witting reaction. And combined with enzymatic cleavage, greatly reducing the reaction time, the total product yield reached 73.2%.