目的评价Perigee系统治疗女性中重度前中盆腔联合缺陷的临床疗效和安全性。方法对2011年10月至2014年1月该院50例盆腔器官脱垂定量(POP-Q)分期法诊断为子宫或膀胱脱垂Ⅲ度及以上患者行Perigee术式,手术前后采用POP-Q、盆底功能障碍问卷(PFDI-20)、性生活质量问卷(PISQ-12)对各项指标及网片相关并发症发生情况进行分析。结果平均手术时间(70.31±15.86)min,术中平均出血(61.56±45.02)ml,术后随访4~27个月(中位随访时间21个月)。客观治愈率93.5%,主观治愈率100.0%;PFDI-20评分较术前显著改善;有性生活患者6例,手术前后性生活质量无明显变化。术后发生网片暴露1例(2.2%);新发压力性尿失禁2例(4.3%);新发阴道后壁脱垂3例(6.5%);阴道挛缩1例(2.2%);无严重并发症发生。结论 Perigee系统是治疗中重度前中盆腔联合缺陷的安全、有效术式,长期疗效及并发症待进一步随访。 Objective To evaluate the clinical efficacy and safety of Perigee system in the treatment of moderate to severe pelvic joint defects in women. Methods From October 2011 to January 2014, 50 patients with pelvic organ prolapse quantitative (POP-Q) staging were diagnosed as Perigee operation with uterine or bladder prolapse of Ⅲ degree or above. The patients were treated with POP-Q , Pelvic floor dysfunction questionnaire (PFDI-20), and quality of life questionnaire (PISQ-12) were used to analyze the indicators and the incidence of complications related to mesh. Results The mean operative time was (70.31 ± 15.86) min. The mean intraoperative bleeding was (61.56 ± 45.02) ml. The patients were followed up for 4 to 27 months (median, 21 months). The objective cure rate was 93.5% and the subjective cure rate was 100.0%. The score of PFDI-20 was significantly improved compared with that before operation. There were 6 patients with sexual life without significant changes in the quality of life before and after surgery. There were 1 case (2.2%) of mesh exposure after operation; 2 cases (4.3%) of new stress urinary incontinence; 3 cases of new vaginal posterior wall prolapse (6.5%); 1 case of vaginal contracture (2.2%); Serious complications occur. Conclusion The Perigee system is a safe and effective procedure for the treatment of moderate to severe pelvic anterior pelvic defects. Long-term efficacy and complications are to be followed up.