论文部分内容阅读
目的探讨反复肺炎患儿免疫功能与炎性相关因子变化。方法选取深圳市南山区西丽人民医院2015年2月-2016年1月收治的70例反复肺炎患儿为观察组,另选同期门诊健康体检儿童70例为对照组,对所有受检者血清免疫球蛋白、T细胞亚群、炎性因子水平进行测定,对两组各项指标进行比较。结果观察组免疫球蛋白、T细胞亚群水平与对照组相比,差异有统计学意义(P<0.05);对照组炎性因子水平与观察组相比均明显较低,两组差异有统计学意义(P<0.05)。结论反复肺炎患儿免疫球蛋与T细胞亚群呈低水平表达,炎性因子呈高水平表达,其体液与细胞免疫功能紊乱,呼吸系统防御能力下降可能是反复肺炎发生的原因之一。
Objective To investigate the changes of immune function and inflammatory factors in children with recurrent pneumonia. Methods Seventy patients with recurrent pneumonia admitted to Xili People’s Hospital of Nanshan District, Shenzhen from February 2015 to January 2016 were selected as the observation group, and 70 healthy children were selected as the control group in the same period. All subjects’ serum Immunoglobulin, T cell subsets, levels of inflammatory cytokines were measured, the two groups of indicators were compared. Results The levels of immunoglobulin and T lymphocyte subsets in the observation group were significantly lower than those in the control group (P <0.05). The levels of inflammatory cytokines in the control group were significantly lower than those in the observation group Significance (P <0.05). Conclusions Immunoglobulin and T cell subsets in children with recurrent pneumonia show low level expression and high level expression of inflammatory cytokines. The humoral and cellular immune dysfunction and decreased respiratory system defense ability may be one of the causes of recurrent pneumonia.