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目的探讨乙酰肝素酶(HPA)和nm23-H1在鼻咽癌组织中的表达以及与肿瘤侵袭转移的关系。方法用免疫组化技术检测HPA和nm23-H1在60例鼻咽癌组织和20例鼻咽慢性炎症组织中的表达情况,并结合患者的临床病理指标进行分析。结果HPA在鼻咽慢性炎症组织和鼻咽癌组织中的阳性表达率分别为0(0/20)和55.0%(33/60)(P<0.05);nm23-H1在鼻咽慢性炎症组织和鼻咽癌组织中的阳性表达率分别为90.0%(18/20)和53.3%(32/60)(P<0.05)。在鼻咽癌组织中,随着鼻咽癌临床分期和侵袭程度的升级,以及有颈淋巴结转移和远处转移时,HPA阳性表达逐渐增加,而nm23-H1阳性表达逐渐减少(P<0.05);HPA和nm23-H1的表达呈明显负相关(P<0.05)。结论HPA阳性表达和nm23-H1阴性表达的鼻咽癌患者有较高的侵袭转移潜能。
Objective To investigate the expression of heparanase (HPA) and nm23-H1 in nasopharyngeal carcinoma (NPC) and its relationship with tumor invasion and metastasis. Methods Immunohistochemistry was used to detect the expression of HPA and nm23-H1 in 60 cases of nasopharyngeal carcinoma and 20 cases of chronic nasopharyngeal inflammation, and the clinical and pathological parameters were analyzed. Results The positive expression rates of HPA in chronic nasopharyngeal tissues and nasopharyngeal tissues were 0 (0/20) and 55.0% (33/60), respectively (P <0.05) The positive rates of NPC in NPC tissues were 90.0% (18/20) and 53.3% (32/60), respectively (P <0.05). In nasopharyngeal carcinoma, the positive expression of HPA gradually increased while the expression of nm23-H1 decreased gradually (P <0.05) with the escalation of clinical stages and invasion of NPC, as well as the metastasis of cervical lymph nodes and distant metastasis. ; There was a negative correlation between HPA and nm23-H1 (P <0.05). Conclusion HPA positive expression and nm23-H1 negative expression of NPC patients have a higher invasion and metastasis potential.