向周围组织浸润是恶性肿瘤的典型特征,对细胞外基质的溶解是肿瘤细胞向外扩散的基础。近来的研究表明基质金属蛋白酶(matrix metalloproteinases,MMPs)在肿瘤溶解细胞外基质向外侵袭中发挥了重要作用。明胶酶A(gelatinaseA,MMP2)是基质金属蛋白酶的一种,它在乳腺癌、前列腺癌及结肠癌中的研究已有报道[1,2]。我们用逆转录定量PCR方法研究了食管癌患者明胶酶A基因表达的情况,现报道如下。 Infiltration into the surrounding tissues is a typical feature of malignant tumors, the dissolution of the extracellular matrix is ​​the basis for the outward spread of tumor cells. Recent studies have shown that matrix metalloproteinases (MMPs) play an important role in the outward invasion of extracellular matrix by tumors. Gelatinase A (MMP2) is a kind of matrix metalloproteinase, which has been reported in breast cancer, prostate cancer and colon cancer [1,2]. We use reverse transcription quantitative PCR method of gelatinase A gene expression in esophageal cancer patients are reported below.