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心舒宁(Perhexiline maleate或pexid)是一种新的抗心绞痛的药物,用于治疗冠状动脉粥样硬化性心脏病。它的作用是扩张冠状血管,减小阻力,畅通血流,增加对心肌血氧的供给;同时减轻左心室的负荷,相对地降低氧耗量,达到改善心绞痛症状和增加运动耐受量的效果。此外,还有利尿和减轻组织胺引起的支气管痉挛的作用,这就有利于同时患有支气管痉挛和充血性心力衰竭的病人使用。临床效果良好,通过临床实践,认为心舒宁此目前常用的抗心绞痛药物,例如潘生丁,硝酸季戊四醇酯,硝酸脱水山梨醇酯,Alprenolol和pronethalol等为好。
Perhexiline maleate or pexid is a new anti-anginal medicine for the treatment of coronary heart disease. Its role is to dilate coronary vessels, reduce resistance, smooth blood flow and increase the supply of myocardial oxygen; while reducing the load on the left ventricle, and relatively reduce oxygen consumption, to improve the symptoms of angina and increase exercise tolerance effect . In addition, there is diuretic and mitigate histamine-induced bronchospasm, which is conducive to patients with both bronchospasm and congestive heart failure. The clinical effect is good. According to clinical practice, it is believed that the current commonly used anti-anginal drugs such as dipyridamole, pentaerythritol nitrate, sorbitan nitrate ester, Alprenolol and pronethalol are the best ones.