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目的:探讨氯米芬联合暖宫七味丸治疗不孕多囊卵巢综合征的有效性及安全性。方法:前瞻性选取2014年4月至12月我院收治的有生育需求的不孕多囊卵巢综合征患者160例,按数字表随机法分为联合组(n=80)和对照组(n=80)。对照组单纯口服氯米芬治疗,联合组在对照组的基础上进行暖宫七味丸治疗。比较两组疗效、治疗前后的内分泌激素水平、子宫内膜厚度、卵巢体积、月经情况、随访1年妊娠情况及不良反应和并发症发生情况。结果:联合组治疗有效率和随访1年妊娠率分别为97.50%和53.75%,均高于对照组的88.75%和20.00%(P<0.05)。与对照组比较,联合组治疗后的血清黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、睾酮(T)、胰岛素(INS)等内分泌激素水平降低,卵巢体积减小,子宫内膜厚度变薄,月经改善率升高(P<0.05)。与治疗前比较,两组治疗后的血清内分泌激素水平均降低,卵巢体积减小,子宫内膜厚度变薄(P<0.05)。两组治疗及随访期间均无卵巢过度刺激综合征、消化道反应等不良反应和并发症的发生。结论:氯米芬联合暖宫七味丸治疗不孕多囊卵巢综合征疗效显著,可有效调节激素水平,减小子宫内膜厚度和卵巢体积,促进排卵,改善月经状况,提高妊娠率,且无明显的不良反应和并发症发生,具有良好的有效性及安全性,值得临床推广应用。
Objective: To investigate the efficacy and safety of clomiphene in combination with warm Gongqi Qiwei Wan in the treatment of infertility polycystic ovary syndrome. METHODS: A total of 160 infertile women with PCOS who were admitted to our hospital from April to December 2014 were prospectively selected and randomly divided into the control group (n = 80) and n = 80). The control group was treated with clomiphene alone, and the combination group was treated with warm Gongqiweiweiwan on the basis of the control group. The curative effects of both groups were compared before and after treatment with endocrine hormone levels, endometrial thickness, ovarian volume, menstrual conditions, follow-up of 1 year of pregnancy and adverse reactions and complications. Results: The effective rate of the combination group and the 1-year follow-up pregnancy rate were 97.50% and 53.75%, respectively, which were higher than 88.75% and 20.00% (P <0.05) of the control group respectively. Compared with the control group, the serum levels of LH, FSH, E2, T and INS in the combination group decreased after treatment, and the ovarian volume decreased Small, thinner endometrial thickness, improved menstrual rate (P <0.05). Compared with those before treatment, the levels of serum endocrine hormones decreased, the ovarian volume decreased, and the thickness of endometrium became thinner (P <0.05). During the treatment and follow-up, there were no ovarian hyperstimulation syndrome, gastrointestinal reactions and other adverse reactions and complications. Conclusion: Clomiphene combined with warm Gongqi Qiwei pill treatment of infertility polycystic ovary syndrome significant effect, which can effectively regulate hormone levels, reduce endometrial thickness and ovarian volume, promote ovulation, improve menstrual status and improve pregnancy rate, and no Obvious adverse reactions and complications, with good effectiveness and safety, worthy of clinical promotion and application.