文献报道,人血清和小鼠腹腔细胞培养国可检出C_3和C_4前体,而C_5是一种血清糖蛋白,其亚单位结构、激活机制和其生物活性片段的功能均与C_3类似。为测定C_5是否也由天然血清蛋白中的一种前体(Pro-C_5)合成,本文用能合成C_5的小鼠腹腔巨噬细胞的短期组织培养研究C_5分子的生物合成。 It has been reported in the literature that C_3 and C_4 precursors can be detected in human serum and mouse peritoneal cell cultures, whereas C_5 is a serum glycoprotein whose subunit structure, activation mechanism and its biologically active fragments are similar to those of C_3. In order to determine whether C_5 is also synthesized from a pro-C_5 precursor of natural serum protein, the biosynthesis of C_5 molecule was studied in short-term tissue culture of C_5-producing mouse peritoneal macrophages.