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目的:对不同剂量米非司酮治疗子宫肌瘤的临床效果进行观察和探讨。方法:选取我院于2011年12月-2013年12月期间收治的100例子宫肌瘤患者,将患者平均分成对照组和观察组,每组各50例,对照组患者在常规治疗的基础上联合20mg米非司酮进行治疗,观察组患者在常规治疗的基础上联合10mg米非司酮进行治疗,所有患者均连续治疗三个月,观察两组患者在治疗期间所出现的不良反应,同时采用B超对患者子宫肌瘤的三围径线做出测量,比较两组患者的治疗效果。结果:经治疗后,两组患者的子宫肌瘤的体积均有明显缩小,两组无明显差异(P>0.05),在并发症发生方面,观察组共有1例患者出现呕吐,对照组中有14例患者出现不良反应,不良反应发生率为28%,两组差异明显(P<0.05),具有统计学意义。结论:在治疗子宫肌瘤患者的过程中,来非司酮具有良好的治疗效果,但从患者的角度出发,小剂量的用药能够大大减少患者的不良反应发生率。
Objective: To observe and discuss the clinical effect of different doses of mifepristone on uterine fibroids. Methods: A total of 100 patients with uterine fibroids who were treated in our hospital from December 2011 to December 2013 were selected. The patients were divided equally into the control group and the observation group, with 50 cases in each group. The patients in the control group were treated on the basis of conventional treatment Combined with 20mg mifepristone treatment, the observation group patients on the basis of conventional treatment combined with 10mg mifepristone treatment, all patients were treated for three months, the two groups observed during treatment of adverse reactions, at the same time Using B-ultrasound on the uterine fibroids in patients with measurements of three-dimensional line to compare the therapeutic effect of two groups of patients. Results: After treatment, the volume of uterine fibroids in both groups were significantly reduced, there was no significant difference between the two groups (P> 0.05), in the incidence of complications, the observation group a total of 1 patients vomiting, the control group Adverse reactions occurred in 14 patients, with a 28% incidence of adverse reactions, with significant differences between the two groups (P <0.05), with statistical significance. CONCLUSION: In the treatment of patients with uterine fibroids, the efficacy of lepisone has a good therapeutic effect, but from a patient’s point of view, small doses of medication can greatly reduce the incidence of adverse reactions in patients.