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目的探讨偏头痛患者血浆内皮素与降钙素基因相关肽变化的临床意义。方法检测51例偏头痛患者发作期与间歇期的EF-1与CGRP的数值,并与对照组进行比较分析。结果检测结果发现偏头痛者血浆内皮素高于对照组,而降钙素基因相关肽低于对照组;发作期与间歇期比较,内皮素与降钙素基因相关肽均有显著差异(P<0.01)。结论检测结果提示偏头痛患者血管内系统存在异常,对偏头痛的临床诊断具有重要意义。
Objective To investigate the clinical significance of plasma endothelin and calcitonin gene-related peptide in migraine patients. Methods The values of EF-1 and CGRP in 51 migraineurs during the onset and intermission were detected and compared with the control group. Results The results showed that plasma endothelin in migraine was higher than that in control group, while calcitonin gene-related peptide was lower than control group. There was significant difference between endothelin and calcitonin gene-related peptide in seizure phase and intermittent phase (P < 0.01). Conclusions The test results suggest that the intravascular system of migraine patients is abnormal, which is of great significance for the clinical diagnosis of migraine.