论文部分内容阅读
目的:优化伏立康唑磺丁基醚-β-环糊精包合物的制备工艺。方法:采用振荡法制备伏立康唑磺丁基醚-β-环糊精包合物,将伏立康唑包合率作为指标,采用星点设计法,设定三因素五水平考察包合温度、包合时间、磺丁基醚-β-环糊精与伏立康唑投料比对包合工艺的影响,并分别进行多元线性、二项式方程和三项式方程拟合,建立模型,效应面法选取最优工艺。结果:伏立康唑磺丁基醚-β-环糊精包合工艺为:包合温度32℃、时间1.9 h、磺丁基醚-β-环糊精与伏立康唑投料比2.1∶1,伏立康唑的包合率预测值与实际值的偏差为2.6%。结论:以星点设计-效应面法建立的数学模型预测效果良好,该方法适用于伏立康唑磺丁基醚-β-环糊精包合物的制备工艺优化。
Objective: To optimize the preparation of voriconazole sulfobutyl ether-β-cyclodextrin inclusion compound. Methods: Voriconazole sulfobutyl ether-β-cyclodextrin inclusion complex was prepared by oscillating method. The inclusion rate of voriconazole was used as an index. The three-factor and five-level design was adopted to study the inclusion temperature, inclusion time, The effects of sulfobutyl ether-β-cyclodextrin and voriconazole on the inclusion process were studied. The multivariate linear, binomial and triadic equations were fitted to establish the model, and the response surface method was used to select the optimal process. Results: The inclusion process of voriconazole sulfobutyl ether-β-cyclodextrin was as follows: the inclusion temperature was 32 ℃, the time was 1.9 h, the dosage of sulfobutylether-β-cyclodextrin and voriconazole was 2.1:1, the inclusion of voriconazole The deviation between predicted and actual values is 2.6%. Conclusion: The mathematical model established by the star-point design-response surface method has a good predictive effect. This method is suitable for the preparation of voriconazole sulfobutylether-β-cyclodextrin inclusion complex.