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目的探讨丙氨酰-谷氨酰胺(Ala-Gln)对脑血管意外昏迷患者免疫功能的影响。方法选取ICU脑血管意外昏迷患者71例,随机分为两组:Ala-Gln组(n=36)为Ala-Gln干预治疗,入院后每日静脉滴注Ala-Gln 100 ml,连续使用15 d;常规组(n=35),不使用Ala-Gln。两组均于入院第1天、第7天、第15天采血检测患者白介素-2(IL-2)、T细胞亚群(CD3、CD4、CD8、CD4/CD8)、免疫球蛋白(IgA、IgG、IgM)水平。结果Ala-Gln组与常规组相比,IL-2、CD3、CD4细胞比例,CD4/CD8比值及IgG、IgA明显升高,且改善时间更早。结论肠外补充Ala-Gln有助于改善脑血管意外昏迷患者的免疫功能。
Objective To investigate the effect of alanyl-glutamine on immune function in patients with cerebrovascular accidental coma. Methods 71 ICU patients with cerebrovascular accidental coma were randomly divided into two groups: Ala-Gln group (n = 36) treated with Ala-Gln. Ala-Gln was intravenously dripped 100 ml intravenously after admission for 15 days ; Conventional group (n = 35), without Ala-Gln. The levels of IL-2, T lymphocyte subsets (CD3, CD4, CD8, CD4 / CD8), IgA, IgG, IgM) levels. Results Compared with the normal group, the ratio of IL-2, CD3 and CD4, the ratio of CD4 / CD8, IgG and IgA in Ala-Gln group were significantly increased and the improvement time was earlier. Conclusion Parenteral Ala-Gln supplementation may improve immune function in patients with cerebrovascular accidental coma.