目的为了解掌握来宾市婚检人群地中海贫血(以下简称地贫)现状,制定有效干预措施。方法采用血细胞21项分析法,对来宾市兴宾区20 015对40 030人婚检对象进行地贫筛查,筛查阳性者进行血红蛋白电泳测定,凡红细胞平均体积(MCV)≤82或平均血红蛋白量(MCH)≤27,均判定为地贫筛查阳性。结果检出地贫阳性3 985人,阳性率9.96%,远高于全国平均(2.64%),检出男女双方均为阳性208对416人,初筛风险率1.04%。对检出一方或者双方是阳性者均给予婚育指导。结论对婚检人群进行地贫筛查,阳性者建立档案进行追踪,怀孕时建议做胎儿地贫筛查诊断,对预防地贫发生有重要意义。 Objective To understand the status quo of pre-marital examination in Laibin city of thalassemia (hereinafter referred to as thalassemia) to develop effective interventions. Methods Twenty-one hundred and seventy 030 premarital subjects in Xingbin district, Laibin city were screened for thalassemia using 21 assays of blood cells. Hemoglobin electrophoresis was performed on those who were screened positive. Where the average volume of erythrocytes (MCV) ≤82 or the average hemoglobin (MCH) ≤ 27, were found to be thalassemia positive screening. Results The positive rate of thalassemia was 3 985 (9.96%), which was much higher than the national average (2.64%). There were 208 pairs of 416 positive men and women, and the risk of primary screening was 1.04%. On the detection of one or both are positive for marriage and childbirth guidance. Conclusions The screening of thalassemia patients for thalassemia, the positive person to establish a file to track, pregnancy is recommended to do fetal thalassemia screening diagnosis, prevention of thalassemia is of great significance.