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为了研究β3肾上腺素受体在持续房颤心房重构中的作用,本研究选择实验犬21只,随机分为假手术组(n=7)、房颤组(n=7)和抑制剂组(n=7)。无菌条件下开胸后在犬右心耳缝植螺旋型起搏电极,连接实验用埋藏式高频起搏器(起搏模式AOO,600次/min),同时抑制剂组犬埋置持续给药泵,假手术组犬仅缝植起搏电极但不起搏,另2组犬心房快速起搏4周。分别于起搏前、起博4周后,检测记录各组犬房颤诱发情况;测量各组犬LAVmax、LAVmin和LAEF;测定左心耳LAAVmax,LAAVmin和LAAEF。我们发现起搏4周后,与假手术组相比,房颤组犬LAVmax、LAVmin、LAAVmax和LAAVmin均显著增加(p<0.01),LAEF和LAAEF均明显下降(p<0.01)。抑制剂组犬LAVmax、LAVmin、LAAVmax和LAAVmin均较房颤组有所降低(p<0.01),而LAEF(p<0.01)和LAAEF增加(p<0.05)。假手术组和抑制剂组两组间比较可见显著差异。结果表明β3受体抑制剂能够减轻心房快速起搏犬心房结构重构和收缩功能降低,有益于防治房颤的心房结构重构。
In order to investigate the role of β3 adrenergic receptors in atrial fibrillation in patients with persistent atrial fibrillation, 21 dogs were randomly divided into sham operation group (n = 7), atrial fibrillation group (n = 7) and inhibitor group (n = 7). Under aseptic conditions, a spiral pacing electrode was sewed in the canine right atrium after thoracotomy. The implanted high frequency pacemaker (AOO, pacing mode: 600 beats / min) was used in the experiment. At the same time, Drug pump, sham-operated dogs only sewed pacing electrodes without pacing, the other 2 dogs atrial pacing for 4 weeks. Four weeks after pacing, the evoked status of atrial fibrillation was recorded and recorded in each group. LAVmax, LAVmin and LAEF were measured in each group. LAAVmax, LAAVmin and LAAEF in left atrial appendage were measured. We found that the LAVmax, LAVmin, LAAVmax and LAAVmin were significantly increased (p <0.01) and both LAEF and LAAEF were significantly decreased (p <0.01) in the atrial fibrillation group after 4 weeks of pacing. LAVmax, LAVmin, LAAVmax and LAAVmin in inhibitor group were lower than those in atrial fibrillation group (p <0.01), while LAEF (p <0.01) and LAAEF increased (p <0.05). There were significant differences between sham and inhibitor groups. The results show that β3 receptor inhibitors can reduce atrial pacing canine atrial structural remodeling and contractile function decreased, is conducive to the prevention and treatment of atrial fibrillation atrial structural remodeling.