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目的:探讨土茯苓体外抗HCMV的效果和安全性。方法:用细胞病变法和MTT法,检测土茯苓体外抗人巨细胞病毒的最大无毒浓度、最小有效浓度和治疗指数,并与更昔洛韦、复方中药金叶败毒进行比较。结果:更昔洛韦、金叶败毒、土茯苓的最大无毒浓度分别为10μg/ml、3000μg/ml、30000μg/ml,最小有效浓度分别为10μg/ml、300μg/ml、300μg/ml,治疗指数分别为1、10、100。结论:土茯苓细胞毒性略低于金叶败毒,大大低于更昔洛韦;抗HCMV效果与金叶败毒相同,略低于更昔洛韦;治疗指数最高,有可能成为治疗HCMV活动性感染的药物。
Objective: To investigate the anti-HCMV efficacy and safety of soil lice in vitro. Methods: The cytotoxicity assay and MTT assay were used to detect the maximum non-toxic concentration, minimum effective concentration and therapeutic index of anti-human cytomegalovirus in vitro, and compared with ganciclovir and compound Chinese herbal medicine. Results: The maximal non-toxic concentrations of ganciclovir, flavonoids and saponins were 10 μg/ml, 3000 μg/ml, and 30000 μg/ml respectively. The minimum effective concentrations were 10 μg/ml, 300 μg/ml, and 300 μg/ml, respectively. The therapeutic indices were 1, 10, and 100, respectively. Conclusion: The cytotoxicity of Smilax glabra is slightly lower than that of S. aureus, which is much lower than that of ganciclovir. The anti-HCMV effect is the same as that of golden leaf sepsis and is slightly lower than that of ganciclovir. The highest treatment index is that it may become a treatment for HCMV activity. Sexually infected drugs.