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目的:利用多种免疫学方法研究民族药沙红合剂对小鼠免疫功能的影响。方法:测定小鼠脾细胞对刀豆蛋白A(ConA)和细菌脂多糖(LPS)的增殖反应、混合淋巴细胞反应(MLR)、溶血空斑试验、DTH反应和NK细胞活性。结果:沙红合剂能非特异地(多克隆)增强T、B淋巴细胞对丝裂原的增殖反应;特异地增强T细胞对异型抗原的MLR、DTH反应;特异地增强小鼠对绵羊红细胞(SRBC)的抗体反应;明显增强小鼠NK细胞的活性。结论:沙红合剂对正常小鼠的细胞免疫功能和体液免疫功能确有明显的促进作用。
OBJECTIVE: To study the effect of the national medicine Shahong Mixture on the immune function of mice by using various immunological methods. METHODS: The proliferation of mouse splenocytes against concanavalin A (ConA) and bacterial lipopolysaccharide (LPS), mixed lymphocyte reaction (MLR), hemolytic plaque assay, DTH response, and NK cell activity were determined. RESULTS: Sha Hong He non-specifically (polyclonally) enhanced the proliferative response of T and B lymphocytes to mitogen; specifically enhanced the MLR and DTH responses of T cells to heterotypic antigens; specifically enhanced mouse to red blood cells of sheep (SRBC ) antibody response; significantly enhanced mouse NK cell activity. Conclusion: Shahong mixture can obviously promote the cellular immunity and humoral immunity of normal mice.