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了解缬草提取物对心肌缺血再灌注损伤的保护作用。方法：大耳白种家兔２０只，分为实验组和对照组。结扎冠状动脉左室支１ｈ后松解，观察１．５ ｈ。实验组手术前１ｈ，结扎前１０ｍｉｎ给予缬草提取物１００ｍｇ／ｋｇ（体重）腹腔注射。观察体表标测心电图、心肌ＳＯＤ：ＭＤＡ、ＴＸＢ_２、６－Ｋｅｔｏ－ＰＧＦ_１α、ＴＮＦ－α、ＩＬ－β等指标。结果：心电图：结扎后１ｈ，实验组Ｎ－ＳＴ、ΣＳＴ、Ｎ．Ｒ明显低于对照组（ Ｐ＜ ０ ．０５）；松解复灌后１．５ｈ，实验组Ｎ－ＳＴ、ΣＳＴ明显低于对照组（ Ｐ＜ ０．０５）。心肌匀浆：实验组ＸＯＤ、ＭＤＡ、ＴＮＦ－α均低于对照组（ Ｐ＜ ０．０５）；实验组６－Ｋｅｔｏ－ＰＧＦ_(１α)／ＴＸＢ_２高于对照组（Ｐ＜０．０５）。实验组ＩＬ－１β略低于对照组，但统计学上无显著差异。结论：缬草提取物有抗心肌缺血再灌注损伤的作用。
To understand the protective effect of Valerian extract on myocardial ischemia-reperfusion injury. Methods: Twenty rabbits with big ears and white species were divided into experimental group and control group. After ligation of the left ventricular branch of the coronary artery for 1 h, release was observed and observed for 1.5 h. In the experimental group, 1 h before surgery, 100 mg/kg (body weight) of Valerian herb extract was given intraperitoneally 10 min before ligation. Observe the surface ECG, myocardial SOD: MDA, TXB_2, 6-Keto-PGF_1α, TNF-α, IL-β and other indicators. Results: Electrocardiogram: 1 hour after ligation, experimental group N-ST, ΣST, N. R was significantly lower than that of the control group (P<0.05). After 1.5 hours of resolvation, the N-ST and AST levels in the experimental group were significantly lower than those in the control group (P<0.05). Myocardium homogenate: XOD, MDA, and TNF-α in the experimental group were lower than those in the control group (P<0.05); 6-Keto-PGF_(1α)/TXB_2 was higher in the experimental group than in the control group (P<0.05). The experimental group IL-1β was slightly lower than the control group, but there was no statistically significant difference. Conclusion: The extract of Valerian has anti-myocardial ischemia-reperfusion injury.