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目的:探讨联合使用兰索拉唑和盐酸伊托必利片对存在特殊症状的胃食管反流病患者进行治疗的临床效果。方法:对2012年2月~2014年2月期间我院收治的80例存在特殊症状的胃食管反流病患者的临床资料进行回顾性研究。我们将这80例患者随机分为观察组和对照组,每组各有40例患者。我院使用兰索拉唑对对照组患者进行治疗,联合使用兰索拉唑(用法与对照组患者相同)和盐酸伊托必利片对观察组患者进行治疗。治疗结束后,比较两组患者治疗的效果和不良反应的发生率。结果:观察组患者治疗的总有效率明显高于对照组患者,二者相比差异具有显著性(P<0.05)。在治疗期间,两组患者均未发生明显的不良反应,二者相比差异无显著性(P>0.05)。结论:联合使用兰索拉唑和盐酸伊托必利片对存在特殊症状的胃食管反流病患者进行治疗的效果确切,而且十分安全。此联合用药方法可作为临床上对存在特殊症状的胃食管反流病患者进行治疗的优选方法。
Objective: To investigate the clinical effect of combined use of lansoprazole and itopride hydrochloride tablets in the treatment of gastroesophageal reflux disease patients with special symptoms. Methods: The clinical data of 80 patients with gastroesophageal reflux disease who were treated in our hospital from February 2012 to February 2014 were retrospectively studied. We randomly divided these 80 patients into observation and control groups, each with 40 patients in each group. In our hospital, patients in the control group were treated with lansoprazole, and patients in the observation group were treated with lansoprazole (the same as the control group) and itopride hydrochloride tablets. After treatment, the effect of treatment and the incidence of adverse reactions in both groups were compared. Results: The total effective rate of observation group was significantly higher than that of control group, the difference was significant (P <0.05). During the treatment, no significant adverse reactions occurred in both groups, with no significant difference between the two groups (P> 0.05). Conclusions: The combination of lansoprazole and itopride hydrochloride tablets is effective and safe for the treatment of patients with gastroesophageal reflux disease with specific symptoms. This combination therapy can be used as a clinical treatment of patients with specific symptoms of gastroesophageal reflux disease is the preferred method.