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目的比较不同质子泵抑制剂(PPI)和抗生素三联疗法治疗幽门螺杆菌(Hp)阳性糜烂性胃炎的疗效差异。方法将Hp阳性糜烂性胃炎545例随机给予奥美拉唑、埃索美拉唑、泮托拉唑、兰索拉唑或雷贝拉唑联合阿莫西林与克拉霉素三联疗法治疗7 d,比较各组疗效差异。结果埃索美拉唑组在缓解症状、改善胃镜下表现方面显著高于其它各组,雷贝拉唑组Hp根除率显著高于其它各组。结论不同PPI治疗Hp阳性慢性糜烂性胃炎的疗效具有差异。
Objective To compare the efficacy of different proton pump inhibitors (PPI) and antibiotics triple therapy in the treatment of Helicobacter pylori (Hp) -positive erosive gastritis. Methods 545 cases of Hp positive erosive gastritis were randomly assigned to omeprazole, esomeprazole, pantoprazole, lansoprazole or rabeprazole combined with amoxicillin and clarithromycin triple therapy for 7 days, Compare the difference between each group. Results Esomeprazole group in relieving symptoms and improving gastroscope performance was significantly higher than the other groups, rabeprazole group Hp eradication rate was significantly higher than the other groups. Conclusion Different PPI treatment of Hp-positive chronic erosive gastritis have different efficacy.