光动力疗法(Photodynamic therapy,PDT)因具有作用精确、毒副作用小、可重复治疗等优点,已广泛应用于恶性肿瘤、血管病变和感染性疾病的治疗。本文将从三个方面分别介绍光动力疗法治疗多种消化道疾病的经验以及在新适应证拓展研究中的体会。主要包括:肿瘤靶向光动力疗法治疗食管癌、胃癌、肠癌以及相关的癌前病变,血管靶向光动力疗法治疗胃窦毛细血管扩张症、放射性胃肠炎等良性血管病 Photodynamic therapy (PDT) has been widely used in the treatment of malignant tumors, vascular diseases and infectious diseases due to its advantages of precise effect, small toxic and side effects, and repeatable treatment. This article will introduce the experience of photodynamic therapy in treating various digestive diseases from three aspects and the experience in the research of new indications. Mainly include: tumor-targeted photodynamic therapy for esophageal cancer, gastric cancer, colorectal cancer and related precancerous lesions, vascular targeted photodynamic therapy for the treatment of gastric capillary telangiectasia, radiation gastroenteritis and other benign vascular disease