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目的:探讨姜黄素对支气管哮喘大鼠气道重塑及核因子-κB(NF-κB)的影响。方法:将Wistar大鼠随机分为对照组、哮喘组、姜黄素组,各10只;采用卵蛋白(OVA)致敏复制大鼠哮喘模型。观察3组大鼠气道炎症、气道壁厚度、胶原沉积及NF-κB和转化生长因子(TGF-β1)表达情况。结果:哮喘组大鼠炎性细胞浸润、胶原沉积、气道壁厚度、NF-κB、TGF-β1表达与对照组比较有显著性差异(P<0.01),而姜黄素组较哮喘组明显减轻(P<0.01);NF-κB与TGF-β1表达、气道炎症、气道壁厚度、胶原沉积变化成正相关(P<0.01)。结论:姜黄素可抑制哮喘大鼠NF-κB活性以干预其气道重塑。
Objective: To investigate the effect of curcumin on airway remodeling and nuclear factor-κB (NF-κB) in bronchial asthmatic rats. Methods: Wistar rats were randomly divided into control group, asthma group and curcumin group, with 10 rats each. The asthma model was induced by ovalbumin (OVA) sensitization. The airway inflammation, airway wall thickness, collagen deposition and the expression of NF-κB and TGF-β1 in the three groups were observed. Results: The expression of inflammatory cell infiltration, collagen deposition, airway wall thickness, NF-κB and TGF-β1 in asthma group were significantly different from those in control group (P <0.01), but curcumin group was significantly lower than that in asthma group (P <0.01). NF-κB was positively correlated with TGF-β1 expression, airway inflammation, airway wall thickness and collagen deposition (P <0.01). Conclusion: Curcumin can inhibit the NF-κB activity in asthmatic rats to interfere with airway remodeling.