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目的:总结我们单中心自2011年12月以来在处理氯胺酮排尿障碍方面的经验。方法:基线资料以及在标准化的四级治疗方法后的治疗结果从我们前瞻性收集的数据库中复查。同时也将讨论治疗结果的可能预测因素。结果:对540名患者的资料进行了审查,患者平均年龄25.2岁。平均氯胺酮使用时间为85个月。经历下尿路症状的时间中位数为24个月。排尿量、膀胱容量和膀胱排空效率的平均值分别为110.1 ml,151.3 ml和78.1%。参加复诊的患者当中,339名用了一线治疗,92名需要使用二线治疗。22名患者接受了膀胱灌注疗法来控制症状。3名患者在该报告期间接受了外科手术。从结果看,一线及二线治疗都能有效改善症状和尿动力学参数。结合戒毒与药物治疗比单独的药物治疗疗效更好。129名患者报告了不良反应,所有都与一线治疗有关。二线及三线治疗后无不良反应。结论:滥用氯胺酮可导致严重的排尿症状。戒除氯胺酮仍然是治疗成功的重要因素。
Objectives: To summarize our experience with treating single ketamine dysuria in our single center since December 2011. METHODS: Baseline data and the results of the treatment following standardized quadruple treatment were reviewed from our prospectively collected databases. The possible predictors of treatment outcome will also be discussed. Results: Data on 540 patients were reviewed, with a mean age of 25.2 years. The average ketamine use time is 85 months. The median duration of lower urinary tract symptoms was 24 months. Urine volume, bladder volume and bladder emptying efficiency averaged 110.1 ml, 151.3 ml, and 78.1%, respectively. Of the patients attending the referral, 339 were first-line and 92 required second-line treatment. Twenty-two patients received bladder irrigation to control symptoms. Three patients underwent surgery during the reporting period. From the results, first-line and second-line treatment can effectively improve the symptoms and urodynamic parameters. Combination detoxification and drug treatment than the drug treatment alone better. 129 patients reported adverse reactions, all related to first-line treatment. No adverse reactions after second and third line treatment. Conclusion: Ketamine abuse can cause severe urination symptoms. Withdrawal of ketamine is still an important factor in the success of treatment.