目的探讨补充乳清蛋白对超重和肥胖成人体重、体成分的影响。方法检索2013年9月前发表的随机对照研究,Meta分析计算加权均数差(WMD)及95%可信区间(95%CI)作为合并效应值,并作分层分析和灵敏度分析。结果12篇纳入的文献中,观察补充乳清蛋白后体重、瘦体组织、脂肪质量的文献分别为9、10、10篇。与对照组相比,补充乳清蛋白后体重、瘦体组织和脂肪质量的合并效应值分别为-1.30 kg(95%CI:-3.53~0.93),1.35 kg(95%CI:0.20~2.51)和-1.24 kg(95%CI:-2.02~-0.47)。分层分析发现研究对象为男性、干预剂量≥52 g,同时伴有运动训练、保持能量摄取不变的情况下效果更加明显。结论超重和肥胖者补充乳清蛋白显著增加瘦体组织和减少脂肪质量,在使用乳清蛋白改善体成分时,要考虑充足的剂量并建议运动训练。 Objective To investigate the effects of whey protein supplementation on body weight and body composition of overweight and obese adults. Methods A randomized controlled study published before September 2013 was performed. Meta-analysis was used to calculate the weighted mean difference (WMD) and 95% confidence interval (95% CI) as the combined effect values ​​for stratified analysis and sensitivity analysis. Results Among the 12 articles included, there were 9, 10 and 10 articles, respectively, on body weight, lean body mass and fat mass after whey protein supplement. Compared with the control group, the combined effects of body weight, lean body mass and fat mass after whey supplementation were -1.30 kg (95% CI: -3.53-0.93), 1.35 kg (95% CI: 0.20-2.51) And -1.24 kg (95% CI: -2.02 ~ -0.47). Hierarchical analysis found that the study object for men, the intervention dose ≥ 52 g, accompanied by exercise training, to maintain the same energy intake effect is more obvious. Conclusions Supplementing whey protein in overweight and obese subjects significantly increased lean body tissue and reduced fat mass. Adequate doses should be considered when using whey protein to improve body composition and exercise training is recommended.