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田鼠经氯林可霉素或(和)万古霉素处理后,分别饲养于常规动物室和有防止交叉感染措施的洁净动物室中,以研究由艰难梭菌引起抗生素—相关结肠炎的流行病学情况。60～100克的叙利亚田鼠经氯林可霉素一次注射100mg/kg后,在常规室(10/10)与洁净室(9/10)均于3～4天内因出血性盲肠炎而死亡。死鼠盲肠内含物均检出艰难梭菌及其毒素。从这一结果判断,外源性感染可能不是主要原因。但经万古霉素每天2～3mg/kg口服10～20天停药后分别饲养的田鼠,在常规室中75%(15/20)于5.5±0.7天死亡;而洁净室中只有5%(1/20)于第14天死亡。两者有显著差别(P<0.01)。注射氯林可霉素前口服万古霉素10～20天在洁净动
The voles were treated with clindamycin or vancomycin and were housed in routine animal houses and clean animal houses with cross-contamination prevention measures to study the epidemiology of antibiotic-associated colitis caused by C. difficile Learning situation. Syrian voles (60 to 100 g) died of hemorrhagic appendicitis within 3 to 4 days in a conventional room (10/10) and a clean room (9/10) after one injection of clindamycin at a dose of 100 mg / kg. Clostridium difficile and its toxins were detected in dead cecal contents. Judging from this result, exogenous infection may not be the main reason. However, voles fed separately after 2 to 3 mg / kg of vancomycin were orally administered 10 to 20 days after oral administration were killed at 5.5 ± 0.7 days in 75% (15/20) of the conventional ones, whereas only 5% 1/20) died on the 14th day. There was a significant difference between the two (P <0.01). Before injection of clindamycin oral vancomycin 10 to 20 days in the clean move