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目的:探讨金石饮方剂联合体外冲击波碎石治疗泌尿系结石的疗效及对患者血脂的影响。方法:120例符合纳入标准的泌尿系结石患者按治疗方案分为对照组(n=60)和观察组(n=60)。对照组给予体外冲击波碎石治疗,观察组在对照组的基础上给予金石饮方剂治疗,并随访1年。观察比较两组患者治疗疗效、复发率、尿培养结果及血脂变化情况。结果:观察组的治疗总有效率为96.7%,明显高于对照组83.3%的总有效率(P<0.05)。随访1年,观察组的复发率为1.7%,明显低于对照组13.0%的复发率(P<0.05)。与对照组相比,观察组治疗后尿培养结果阳性比例降低,血脂指标总胆固醇(total cholesterol,TC),甘油三酯(triglyceride,TG),低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)明显下降,高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)明显增高,比较均有统计学意义(均P<0.05)。结论:金石饮方剂联合体外冲击波碎石是泌尿系结石的一种有效治疗方案,可以提高疗效,减少复发及泌尿系感染,并有效调节血脂,临床上值得进一步研究。
Objective: To investigate the curative effect of Jinshikang combined with extracorporeal shock wave lithotripsy on urinary calculi and its effect on the blood lipid of patients. Methods: One hundred and twenty patients with urolithiasis were divided into control group (n = 60) and observation group (n = 60) according to the treatment plan. The control group was treated with extracorporeal shock wave lithotripsy. The observation group was treated with Jinshiyin recipe on the basis of the control group and followed up for 1 year. The curative effect, recurrence rate, urine culture results and blood lipid changes of the two groups were observed and compared. Results: The total effective rate of the observation group was 96.7%, significantly higher than that of the control group 83.3% (P <0.05). The follow-up of 1 year, the recurrence rate of the observation group was 1.7%, significantly lower than the control group 13.0% of the recurrence rate (P <0.05). Compared with the control group, the positive rate of urinalysis in the observation group was lower than that of the control group. The levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL) (P <0.05). The levels of HDL-C and HDL-C were significantly decreased (all P <0.05). Conclusion: Jinshijing decoction combined with extracorporeal shock wave lithotripsy is an effective treatment for urolithiasis, which can improve curative effect, reduce recurrence and urinary tract infection, and effectively regulate blood lipids. It is worth further study in clinic.