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目的探讨黄芪对慢性心力衰竭大鼠心功能的保护作用和血清IL-6与TNF-α含量的变化。方法通过腹腔注射阿霉素来建立大鼠的慢性心衰模型,实验分为正常对照组、模型组和黄芪组。黄芪组灌胃给予药物4ml/kg,治疗4周后,对相关指标进行检测。结果与模型组比较,黄芪组有效的降低了左心室质量指数、升高左室收缩压、左室内压最大上升速率和左室内压最大下降速率,降低左室舒张末压,同时降低血清IL-6与TNF-α含量。结论黄芪能够明显的改善阿霉素建立的慢性心衰大鼠的心功能,降低了血清中IL-6与TNF-α含量,推测黄芪改善心功能的作用可能与抑制炎症和心室重塑相关。
Objective To investigate the protective effects of Astragalus on heart function and the changes of serum IL-6 and TNF-α levels in rats with chronic heart failure. Methods The model of chronic heart failure was established by intraperitoneal injection of doxorubicin. The experiment was divided into normal control group, model group and Astragalus group. Astragalus group administered drugs 4ml / kg, after 4 weeks of treatment, the relevant indicators were detected. Results Compared with model group, Astragalus membranaceus effectively reduced left ventricular mass index, increased left ventricular systolic pressure, maximum rate of left ventricular pressure and maximum rate of left ventricular pressure, decreased left ventricular end-diastolic pressure, decreased serum IL- 6 and TNF-α content. Conclusion Astragalus can significantly improve the heart function of rats with chronic heart failure induced by doxorubicin and reduce the levels of IL-6 and TNF-α in serum. It is speculated that the effect of astragalus on cardiac function may be related to the inhibition of inflammation and ventricular remodeling.