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目的探讨糖化血红蛋白(Glycosylated hemoglobin,Hb A1c)、糖化血清蛋白(Glycosylated serum protein,GSP)及空腹血糖(FPG)的检测对糖尿病(DM)诊断、治疗及控制管理的临床价值。方法选择261例经确诊的2型糖尿病患者和62例健康体检者,以酶法分别检测Hb A1c、GSP、FPG含量,并进行比较分析。结果在261例2型糖尿病患者中,Hb A1c、GSP、FPG的升高率分别为54.0%(141/261)、60.9%(159/261)和93.5%(244/261),差异均具有统计学意义(P<0.01)。Hb A1c、GSP、FPG平均含量分别(7.6±1.3)%、(270.4±38.8)μmol/L、(10.5±2.0)mmol/L;62例健康体检者Hb A1c、GSP、FPG含量分别为(4.8±1.2)%、(179.2±57.0)μmol/L和(4.8±1.2)mmol/L,2型糖尿病患者和62例健康体检者比较,差异有统计学意义(P<0.01)。结论在2型糖尿病患者中,FPG阳性率最高,提示FPG为检测即时血糖,受到影响因素多,难以代表患者在管理治疗过程中真实血糖水平。因此,如能联合Hb A1c和GS检测,对糖尿病评价更有意义。
Objective To investigate the clinical value of detecting glycosylated hemoglobin (Hb A1c), glycosylated serum protein (GSP) and fasting blood glucose (FPG) in the diagnosis, treatment and management of diabetes mellitus (DM). Methods Totally 261 patients with type 2 diabetes mellitus and 62 healthy subjects were enrolled in this study. The contents of Hb A1c, GSP and FPG were detected by enzymatic method and compared with each other. Results In 261 type 2 diabetic patients, the rates of Hb A1c, GSP and FPG were 54.0% (141/261), 60.9% (159/261) and 93.5% (244/261), respectively Significance (P <0.01). The average contents of Hb A1c, GSP and FPG were (7.6 ± 1.3)%, (270.4 ± 38.8) μmol / L and (10.5 ± 2.0) mmol / ± 1.2%, (179.2 ± 57.0) μmol / L and (4.8 ± 1.2) mmol / L, respectively. There was significant difference between type 2 diabetic patients and 62 healthy controls (P <0.01). Conclusion The positive rate of FPG is the highest in patients with type 2 diabetes mellitus, suggesting that FPG is a real-time blood glucose measurement and it is difficult to represent the real blood glucose level of patients during management and treatment. Therefore, combined with Hb A1c and GS test, more meaningful for the evaluation of diabetes.