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目的:初步探讨Ⅳ型胶原蛋白(ColⅣ)、层黏连蛋白(LN)在鼻腔鼻窦恶性肿瘤中表达的相关性。方法:用免疫组织化学法检测137例鼻腔鼻窦恶性肿瘤、78例癌旁组织和37例对照组中ColⅣ和LN的表达。结果:ColⅣ和LN在鼻腔鼻窦恶性肿瘤、癌旁组织和对照组中的表达差异有统计学意义(P<0.01),在不同病理类型鼻腔鼻窦恶性肿瘤中的表达差异无统计学意义(P>0.05)。结论:ColⅣ和LN对鼻腔鼻窦恶性肿瘤的发生、发展起一定作用,在不同病理类型鼻腔鼻窦恶性肿瘤中可能发挥相似作用,无组织特异性。
Objective: To investigate the relationship between the expression of collagen type IV (Col IV) and laminin (LN) in malignant tumors of nasal cavity and sinuses. Methods: Immunohistochemistry was used to detect the expression of ColIV and LN in 137 cases of nasal cavity and sinus malignant tumors, 78 cases of adjacent tissues and 37 cases of control group. Results: There were significant differences in the expression of ColIV and LN in malignant sinonasal sinus tumors, adjacent tissues and controls (P<0.01). There was no significant difference in the expression of ColIV and LN among different pathological types of nasal sinus malignant tumors (P> 0.05). Conclusion: ColIV and LN play a certain role in the occurrence and development of malignant tumors of the nasal cavity and sinuses. They may play a similar role in different pathological types of malignant tumors of the nasal cavity and sinuses, and have no tissue specificity.