9例新型冠状病毒无症状感染者的临床特征

来源 :中华实验和临床病毒学杂志 | 被引量 : 0次 | 上传用户:chinajiang
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目的:分析9例新型冠状病毒(2019 novel Coronavirus, 2019-nCoV)无症状感染者的临床特征,为2019-nCoV感染防治提供科学依据。方法:回顾性分析2020年1月21日至2月21日期间石家庄市第五医院收治的9例2019-nCoV无症状感染者的临床资料、实验室检测指标。结果:无症状感染者在各年龄段均有分布,其中男性5人、女性4人。无症状感染者入院第1天,白细胞、淋巴细胞和中性粒细胞的检测值处于正常水平;入院后第3天,检测值增高,持续至入院第12天,结果趋于稳定。谷丙氨酸氨基转移酶、乳酸脱氢酶水平在入院期间处于正常水平,无一过性增高或降低。C反应蛋白水平在入院后第3天达到最高值,但始终在正常范围内。D-二聚体水平在入院期间相对稳定。T细胞亚群绝对值结果显示,无症状感染者在入院第7~15天,CDn 3+、CDn 4+、CDn 8+T细胞水平较入院前升高。无症状感染者咽部核酸检测阳性平均持续时间为11.88 d,ORF1ab基因平均循环阈值为36.94,N基因平均循环阈值为35.43。n 结论:2019-nCoV无症状感染者的炎症反应轻微,机体免疫功能相对较好。“,”Objective:To investigate the clinical data of asymptomatic patients with 2019 novel Coronavirus (2019-nCoV) infection in Shijiazhuang and provide scientific evidence for prevention and treatment of Coronavirus Disease 2019(COVID-19).Methods:Retrospective study was conducted to analyze the clinical features and laboratory data of 9 asymptomatic 2019-nCoV infected patients, admitted to the Fifth Hospital of Shijiazhuang from January 21, 2020 to February 21, 2020.Results:Asymptomatic infection was found in all age groups, including 5 males and 4 females. On the first day of admission, the detection result of leukocytes, lymphocytes and neutrophils in asymptomatic patients were at normal levels. On the third day after admission, the results increased and continued to stabilize on the twelfth day. The levels of alanine aminotransferase and lactate dehydrogenase were at normal levels during hospitalization, without transient increase or decrease. The level of C-reactive protein reached the highest level on the third day after admission, but it was always in the normal range. D-dimer level was relatively stable during hospitalization. The absolute value of T cell subsets showed that the levels of CDn 3+ , CDn 4+ , CDn 8+ T cells in asymptomatic infection patients were higher than those determined before admission. The average duration of pharyngeal nucleic acid positive detection in asymptomatic patients was 11.88 days. The average cycle threshold of ORF1ab gene and N gene was 36.94 and 35.43 respectively.n Conclusions:The inflammatory reaction in patients with asymptomatic 2019-nCoV infection was mild, and the immune function was relatively good.
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