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目的:抗生素后效应(postantibiotic effect,PAE)是指在抗生素短暂作用后,细菌在一定时间内仍被持续抑制的现象。本研究测定了抗菌药大环内酯类、β内酰胺类、环丙沙星及阿米卡星对金葡菌、肺炎链球菌、流感杆菌、大肠埃希菌及肺炎克雷伯菌的PAE,以了解常用抗菌药对临床常见病原菌的PAE。方法:以肉汤稀释法测定抗菌药的MIC,PAE实验中采用洗涤法去除抗菌药,以活菌落计数法测定菌液浓度,并作图,根据公式PAE=T-C计算PAE,T、C分别代表试验管及对照管细菌长1log所需的时间。结果:大环内
OBJECTIVE: Postantibiotic effect (PAE) refers to the phenomenon that bacteria continue to be inhibited for a certain period of time after the short-term effect of antibiotics. This study measured the antibacterials macrolides, β-lactams, ciprofloxacin and amikacin against Staphylococcus aureus, Streptococcus pneumoniae, influenza, Escherichia coli and Klebsiella pneumoniae PAE , In order to understand the commonly used antibacterial drugs PAE of common pathogens. Methods: The antibacterial MICs were determined by broth dilution method. The antibacterials were removed by washing method in PAE experiment. The concentration of bacteria liquid was determined by viable colony counting method. The PAE was calculated according to formula PAE = TC, and T and C were respectively Test tube and control tube bacteria long 1log time required. Results: Inside the ring