多发性乳头状瘤是儿童喉部最常见的良性肿瘤,但即使在较大的儿童医院每年也只见到3～4例新病人。因此,来自各处报导的资料仍不多。这些良性疣状物,象生长在皮肤上的、消化道和生殖道的乳头状瘤一样,具有局部扩散倾向;虽经完全切除,也易复发,最后却又退缩和自行消失。1923年,Ullman确立病毒起源学说,他将喉部切除的乳头状瘤组织注入自己前臂,90天后出现一群扁平疣;然后,将无细胞的浸出物接种臂部,结果情况相同,经同样潜伏期后出现疣状新生物,光镜可在乳头状瘤角化表层中见到包涵体,电镜检查则可在该处肯定病毒颗粒的存在。有时可在尖锐湿疣和生殖道湿疣中见到类似病毒颗粒,但在喉部乳头状瘤则极难见到。病毒 Multiple papilloma is the most common benign tumor in the throat of children, but only 3 to 4 new patients are seen each year, even in larger children’s hospitals. Therefore, there is not much information reported from all over. These benign warts, like the papillomas that grow on the skin, the digestive tract and the genital tract, have a tendency to spread locally; although they are completely resected, they also tend to relapse, and eventually they contract and disappear. In 1923, Ullman established the theory of viral origin by injecting a laryngectomized papilloma tissue into his forearm and a group of flat warts after 90 days; then, cell-free extracts were seeded on the arm and the result was the same. After the same incubation period Emerging from verrucous neoplasms, light microscopy can see inclusions in the keratinized surface of the papilloma and electron microscopy can confirm the presence of the virus particles there. Viroid-like particles can sometimes be seen in genital warts and genital warts, but in papilloma of the larynx it is extremely difficult to see. virus