本实验对喂以胆固醇和猪油的幼家鸽主动脉进行光镜及电镜研究。动物于不同间隔时间处死。实验2周出现早期病变,病变随实验时间的延长而加重;24周以后,出现少数几乎阻塞血管管腔的大斑块。典型斑块由巨噬细胞源性和肌源性两种泡沫细胞组成。实验表明,家鸽具有来源充裕、饲养方便、给药方法简单、剂量控制准确,又能早期有效地诱发主动脉粥样硬化等优点,可作为一种比较理想的动物模型。 In this experiment, the young avenues fed with cholesterol and lard were studied by light and electron microscopy. Animals were sacrificed at different intervals. In the second week of experiment, the early lesions appeared, and the lesions aggravated with the prolongation of experiment time. After 24 weeks, a few large plaques almost blocked the blood vessel lumen. Typical plaques consist of both macrophage-derived and myogenic foam cells. Experiments show that domestic pigeons have ample source, convenient feeding, simple administration method, accurate dose control, and can effectively induce aortic atherosclerosis and other advantages early, can be used as an ideal animal model.