论文部分内容阅读
目的观察重组血小板生成素(rh TPO)与小剂量人血丙种球蛋白治疗特发性小儿血小板减少性紫癜的临床疗效。方法将300例特发性小儿血小板减少性紫癜(ITP)患儿随机分为3组,每组100例。A组皮下注射rh TPO,B组给予糖皮质激素,C组在B组的基础上给予小剂量人血丙种球蛋白,比较3组临床疗效及血小板动态变化情况。结果 A、C组总有效率均高于B组(P<0.05);A组与C组总有效率比较差异无统计学意义(P>0.05)。A、C组各项血小板动态指标均较B组有显著改善(P<0.05)。除出血停止时间外,C组其他指标均优于A组(P<0.05)。结论 rh TPO和糖皮质激素联合小剂量人血丙种球蛋白对小儿血小板减少性紫癜均有良好的治疗效果,后者治疗方案治疗效果更佳。
Objective To observe the clinical efficacy of recombinant rh TPO and low dose human gamma globulin in the treatment of idiopathic thrombocytopenic purpura. Methods 300 children with idiopathic thrombocytopenic purpura (ITP) were randomly divided into three groups (100 in each group). Group A received rh TPO subcutaneously, group B received glucocorticoid, group C received a small dose of human gamma globulin on group B, and the clinical efficacy and platelet dynamics were compared between the three groups. Results The total effective rates of group A and group C were significantly higher than those of group B (P <0.05). There was no significant difference in the total effective rate between group A and group C (P> 0.05). The dynamic indexes of platelet in groups A and C were significantly improved compared with those in group B (P <0.05). Except bleeding time, other indexes in group C were better than those in group A (P <0.05). Conclusion rh TPO and glucocorticoid combined with low-dose human gamma globulin have a good therapeutic effect on pediatric thrombocytopenic purpura, and the latter treatment is better.