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用含 0 75 %腺嘌呤的饲料连续 2 4天喂养大鼠 ,制作成动物肾衰模型 ,造成大鼠贫血 ,再分别采用国产和进口的重组人红细胞生成素 (rhEPO)皮下注射给药 ,观察其对模型动物肾性贫血的作用。结果表明 :国产rhEPO隔日 1次 ,持续注射8周后 ,能使肾衰大鼠的血红蛋白、红细胞和红细胞压积明显上升 ,贫血状态显著改善 ,其作用与进口制剂相似
Rats fed with 0 75% adenine for 24 consecutive days were fed with animal models of renal failure resulting in anemia in rats. Subcutaneous injection of domestic and imported recombinant human erythropoietin (rhEPO) Its effect on renal anemia in model animals. The results showed that domestic rhEPO could improve the hemoglobin, erythrocyte and hematocrit of rats with renal failure by adding it once every other day for 8 weeks and the anemia state was significantly improved, which was similar to that of imported preparations