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目的探讨癌胚抗原 (carcinoembryonicantigen ,CEA)和雌激素受体 (estrogenreceptor,ER)的检测在乳腺癌早期、晚期辅助诊断中的临床意义。方法采用放射免疫技术检测 118例乳腺细针穿刺标本 (6 9例乳腺癌 ,4 9例乳腺良性病变 )中的CEA。并用免疫组化技术检测 6 9例乳腺癌穿刺标本及相应组织切片的ER表达。结果乳腺癌与乳腺良性病变组织中的CEA活性差异有显著意义 (P <0 0 1) ,前者明显升高。乳腺癌细针穿刺标本和组织切片中ER表达有极显著的一致性 (P <0 0 1) ,两者一致率为 90 %。结论细针穿刺取材检测其CEA水平和ER表达 ,有助于早、晚期乳腺癌的诊断和制定合理的治疗方案
Objective To investigate the clinical significance of the detection of carcinoembryonic antigen (CEA) and estrogen receptor (ER) in the early and late diagnosis of breast cancer. Methods Radioimmunoassay was used to detect CEA in 118 cases of fine needle aspiration needle (69 cases of breast cancer and 49 cases of benign breast lesions). Immunohistochemistry was used to detect the expression of ER in 69 specimens of breast cancer and corresponding tissue sections. Results There was significant difference in CEA activity between breast cancer and benign breast lesions (P <0.01), the former was significantly higher. There was a significant consistency of ER expression between fine needle aspiration and tissue sections of breast cancer (P <0.01), with a consistent rate of 90%. Conclusion Fine-needle aspiration (CEA) and ER expression are helpful to diagnose early and advanced breast cancer and to develop a reasonable treatment plan