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儿童系统性硬皮病(JSSc)是以皮肤和器官纤维化为特点的结缔组织病,流行病学不同于成人,发病机制亦尚不明确,但近来表观遗传学提出的为系统性硬皮病(SSc)发病机制的探索打开了新局面;JSSc有其自身的诊断标准,同时,对其病情评估至关重要,其评估方式各有优缺点;JSSc一直以来都没有特别的治疗,表观遗传学的提出为JSSc的治疗提供了一个方向。
Children’s Systemic Scleroderma (JSSc) is a connective tissue disease characterized by fibrosis of the skin and organs. Its epidemiology is different from that of adults. The pathogenesis of JSSc is not yet clear. However, recent epigenetics has proposed a systemic scleroderma The discovery of the pathogenesis of the disease (SSc) has opened the door to new dimensions; JSSc has its own diagnostic criteria and, at the same time, is critically important in the assessment of its condition and has its own strengths and weaknesses; JSSc has never had any special treatment, Genetics offers a direction for the treatment of JSSc.