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目的:探讨奥硝唑(ONZ)、甲硝唑(MNZ)和替硝唑(TNZ)治疗滴虫性阴道炎(TMV)的有效性和安全性,为TMV的治疗提供理论依据。方法:选取2010年10月~2013年10月该院收治的195例TMV患者,分为ONZ组、TNZ组和MNZ组,每组各65例。治疗方案按ONZ、MNZ和TNZ方案执行,治疗后按标准进行疗效和不良反应评定,并对数据进行统计学分析。结果:ONZ组痊愈54例(83.07%),总有效率为98.56%,与其他两组比较,差异有统计学意义(χ2=9.085、9.152,P均<0.05)。ONZ组出现不良反应7例(10.77%),与其他两组比较,差异有统计学意义(χ2=8.645、8.686,P均<0.05)。结论:ONZ方案在疗效和不良反应方面优于MNZ和TNZ组,故临床治疗TMV应优先选择ONZ方案。
Objective: To investigate the efficacy and safety of ornidazole (ONZ), metronidazole (MNZ) and tinidazole (TNZ) in the treatment of trichomonas vaginitis (TMV) and provide a theoretical basis for the treatment of TMV. Methods: Totally 195 TMV patients admitted to our hospital from October 2010 to October 2013 were divided into ONZ group, TNZ group and MNZ group, with 65 cases in each group. The treatment regimen was performed according to the ONZ, MNZ and TNZ regimens. After treatment, the efficacy and adverse reactions were evaluated according to the standard, and the data were statistically analyzed. Results: In ONZ group, 54 cases (83.07%) were cured and the total effective rate was 98.56%. There was significant difference between the two groups (χ2 = 9.085, 9.152, P <0.05). There were 7 adverse reactions (10.77%) in ONZ group, which were statistically significant compared with the other two groups (χ2 = 8.645, 8.686, P <0.05). Conclusion: The ONZ regimen is superior to MNZ and TNZ in curative effect and adverse reaction, so the ONZ regimen should be given priority in the treatment of TMV.