目的:探讨乳腺髓样癌的临床诊治方法。方法:自2011年1月至2013年12月,我院共收治21例乳腺髓样癌患者,通过回顾性患者的临床资料,并根据患者的病情进展制定针对性的治疗方法,探讨临床乳腺髓样癌的诊治方法。结果:本组患者术后病理检验均呈现明显MBC病理反应,肿块呈实质性灰白色,病灶边界清晰;典型髓样癌9例(42.86%),不典型髓样癌12例(57.14%);TNM临床分期中Ⅱ期患者最多(16/76.19%);患者瘤块大小以2~5cm最多(13/61.90%);患者发生腋窝淋巴结转移率为47.62%;雌激素受体(ER)阳性率为38.10%,孕激素受体(PR)阳性率为33.33%,HER2阳性率为33.33%,p53阳性率为66.67%。术后3年的生存率为90.48%;术后5年,生还率为80.95%。结论:根据患者详细全面的临床病理学特征,正确的诊断MBC,根据患者的病情制定针对性的治疗方案,对于提高患者的治疗效果,改善患者生活质量意义重大。 Objective: To investigate the clinical diagnosis and treatment of medullary mammary carcinoma. Methods: From January 2011 to December 2013, a total of 21 patients with medullary carcinoma of the breast were treated in our hospital. The clinical data of the patients were retrospectively analyzed. According to the progress of the patients, we made the targeted treatment and discussed the clinical characteristics of the breast Diagnosis and treatment of cancer. Results: The postoperative pathological examination showed significant pathological changes of MBC. The mass of the tumor was clear gray and the border of the tumor was clear. The typical medullary carcinoma in 9 cases (42.86%), atypical medullary carcinoma in 12 cases (57.14%), TNM The clinical stage of patients with stage Ⅱ was the largest (16 / 76.19%); the size of the tumor was 2 ~ 5cm (13 / 61.90%); the rate of axillary lymph node metastasis was 47.62%; the positive rate of estrogen receptor 38.10%, the positive rate of progesterone receptor (PR) was 33.33%, the positive rate of HER2 was 33.33%, and the positive rate of p53 was 66.67%. After 3 years of survival rate was 90.48%; 5 years after surgery, the survival rate was 80.95%. Conclusion: According to the detailed and comprehensive clinicopathological characteristics of patients, the correct diagnosis of MBC, according to the patient’s condition to develop targeted treatment options for improving the patient’s treatment, improve patient quality of life is significant.