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研究目的 :探索儿童孤独症与染色体脆性的关系。方法 :采用低叶酸TC199培养诱导法 ,对 80名孤独症儿童和 80名正常儿童进行了外周血淋巴细胞染色体脆性位点表达检测和断裂点频率统计。结果 :孤独症组染色体断裂或裂隙的频率为 16 .2 % ,普通型脆性位点表达 15例 (18.75 % ) ,遗传型脆性位点表达 8例 (10 .0 % ) ;与对照组比较 ,差异均有显著性。结论 :认为较高脆性位点表达率和断裂点频率 ,是儿童孤独症患者发病的物质基础和病因之一
Objective: To explore the relationship between autism and chromosomal fragility in children. Methods: Low-folate TC199 culture induction method was used to detect the expression of chromosomal fragile sites in peripheral blood lymphocytes and the frequency of breakpoints in 80 children with autism and 80 normal children. Results: The frequency of chromosome rupture or cleft was 16.2% in autism group, 15 (18.75%) in common type and 10 (10.0%) in genetic type. Compared with control group, The differences were significant. Conclusion: It is considered that the higher expression of brittle locus and the frequency of break point are the material basis and etiological factor of children with autism