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目的 :研究北京、沈阳两个地区汉族人群磺脲受体 (sulfonylureareceptor,SUR)基因第 2 4内含子 3t/c多态性与 2型糖尿病的相关性。方法 :采用配偶对作病例 对照研究。用聚合酶链反应 长度多态性的方法检测磺脲受体基因第 2 4内含子 3t/c多态性。结果 :SUR2 4内含子 3t/c多态性的基因型频率和等位基因频率在 2型糖尿病组和对照组间差异无显著性。结论 :在所筛查的北京、沈阳两地区人群中SUR基因 2 4内含子 3t/c多态性与 2型糖尿病无显著相关性
Objective: To investigate the association between 3t / c polymorphism of intron 2 (s) of sulfonylurea receptor (SUR) gene and type 2 diabetes mellitus in Han population of Beijing and Shenyang. Methods: Using spouse as a case control study. Polymerase chain reaction length polymorphism was used to detect the 3t / c polymorphism of inosetron 24 in the sulfonylurea receptor gene. Results: There was no significant difference in genotype frequency and allele frequency between SUR2 4 intron 3 t / c polymorphism in type 2 diabetes mellitus and controls. CONCLUSION: There is no significant correlation between SUR324 intron 3 t / c polymorphism and type 2 diabetes among the screening population of Beijing and Shenyang