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目的研究硒对实验性大鼠肝纤维化的防治作用．方法Ｗｉｓｔａｒ大鼠８０只，体重１８０ｇ～２２０ｇ，随机分为４组：①正常对照组；②病理模型组，用人血白蛋白诱导肝纤维化，第１步皮下注射致敏４５ｄ，随之静脉注射；③硒防治组，静脉注射４ｗｋ后，以硒溶液灌胃；④秋水仙碱治疗组，静脉注射人血白蛋白１２ｗｋ后，秋水仙碱灌胃．静脉注射结束后，治疗开始后６ｗｋ和１２ｗｋ采集肝组织标本，用光镜和电镜进行肝脏组织学检查．结果硒防治组肝脏纤维化的程度（Ⅰ级２只，Ⅱ级３只，Ⅲ级３只，Ⅳ级１只）明显低于病理模型组（Ⅱ级２只，Ⅲ级３只，Ⅳ级５只，Ⅴ级３只，Ｐ＜００１）硒防治组肝脏超微结构的变化也较轻微．结论硒对实验性大鼠肝纤维化有一定的预防和治疗作用．
Objective To study the preventive and therapeutic effects of selenium on experimental hepatic fibrosis in rats. Methods 80 Wistar rats weighing 180-220 g were randomly divided into 4 groups: ① normal control group; ② pathological model group, induced by hepatic fibrosis with human serum albumin, the first subcutaneous injection of sensitized 45 days, followed by intravenous injection ; ③ selenium prevention and treatment group, 4wk intravenous injection of selenium solution gavage; ④ colchicine treatment group, intravenous injection of human serum albumin 12wk, colchicine gavage. After the intravenous injection, the liver tissues were collected at 6wk and 12wk after the start of treatment, and the liver histological examination was performed with light microscope and electron microscope. Results The degree of hepatic fibrosis in selenium group was significantly lower than that of pathological model group (2 in grade Ⅰ, 3 in grade Ⅱ, 3 in grade Ⅲ and 1 in grade Ⅳ) (2 in grade Ⅱ, 3 in grade Ⅲ and 5 in grade Ⅳ Only Ⅴ grade 3, P <0 01) selenium control group liver ultrastructure changes are minor. Conclusion Selenium has some preventive and therapeutic effects on hepatic fibrosis in experimental rats.