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目的:探讨红花外用微乳制剂的药效学作用。方法:用红花酒精及红花微乳分别经皮给药7 d,用醋酸扭体法测镇痛,小鼠腹腔通透性改变测抗炎,用玻片法测定小鼠的凝血时间和用鼠尾横切法测出血时间,来评价红花外用微乳制剂的药效作用。结果:与空白对照(等体积生理盐水)组相比,红花外用微乳制剂与红花酒精都有较好的镇痛抗炎活血作用,且红花微乳作用强于红花醇。结论:红花外用微乳制剂具有良好的抗炎镇痛活血作用。
Objective: To investigate the pharmacodynamics of safflower external microemulsion. Methods: The safflower alcohol and safflower microemulsion were transdermally administrated for 7 d respectively. Acetic acid writhing method was used to measure the analgesia. Peritoneal permeability test was used to measure the anti-inflammation. The clotting time and The rat tail cross-cut method was used to measure the blood time to evaluate the pharmacodynamic effects of Safflower external microemulsion formulations. Results: Compared with blank control group (equal volume of normal saline), Safflow microemulsion had better analgesic, anti-inflammatory and blood-activating effect than safflower alcohol, and safflower microemulsion was stronger than safflower alcohol. Conclusion: Safflower external microemulsion has good anti-inflammatory and analgesic effects on blood circulation.