阵发性睡眠性血红蛋白尿(paroxysmal nocturnal hemoglobinuria,PNH)是一种罕见的获得性溶血性贫血。本文报道1例以反复流产为表现的PNH患者,并结合文献讨论其特点。病例:患者为女性,33岁,因“流产4次,伴血红蛋白、血小板减少7年余”入院。患者于7年余前发生自发性流产,当时查血常规提示白细胞计数3.3×109/L,血红蛋白106 g/L,血小板计数47×109/L。于当地医院行骨髓穿刺检查,结果提示“增生性骨髓象,巨核系成熟障碍”;同时查自身免疫性疾 Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hemolytic anemia. This article reports a case of recurrent spontaneous abortion PNH patients, and discusses the characteristics of the literature. Case: The patient was female, age 33, hospitalized because of “4 abortion with hemoglobin and thrombocytopenia over 7 years.” Patients spontaneous abortion more than 7 years ago, then check the blood routine prompted leukocyte count 3.3 × 109 / L, hemoglobin 106 g / L, platelet count 47 × 109 / L. At the local hospital bone marrow biopsy, the results suggest that “hyperplastic bone marrow, megakaryocyte maturation disorder”; at the same time check the autoimmune diseases