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甲氟哌酸(培氟沙星)属喹诺酮类抗感染药物,抗菌谱广,口服吸收完全,具有高度的组织渗透力,而且作用持久,每日用药二次,方便病人。甲氟哌酸不良反应较少,主要是消化道不良反应(胃疼、恶心、呕吐)及过敏反应等,但据临床观察,下列药物不宜与其合用: 茶碱类:甲氟哌酸与茶碱合用时抑制茶碱的代谢,提高茶碱血药浓度,因此合用时易使茶碱类血药浓度增高,甚至蓄积。应注意合用时适当减少茶碱类药物剂量及监测茶碱浓度。
Cofloxacin (pefloxacin) is quinolone anti-infective drugs, broad antibacterial spectrum, oral absorption is complete, with a high degree of tissue penetration, and the role of long-lasting, twice daily medication to facilitate the patient. Mefloxacin less adverse reactions, mainly gastrointestinal adverse reactions (stomach pain, nausea, vomiting) and allergic reactions, but according to clinical observations, the following drugs should not be combined with: theophylline: mefloxacin and theophylline Combination inhibition of theophylline metabolism and improve theophylline plasma concentration, so when combined with theophylline-prone plasma concentration, or even accumulation. Should pay attention to the appropriate reduction of theophylline dose and monitoring theophylline concentration.