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目的比较两种不同途径的新辅助化疗在ⅠB2~ⅡB期局部晚期宫颈癌治疗中的临床疗效,以期更好的指导临床。方法分析新疆医科大学附属肿瘤医院2008年2月~2009年12月治疗的142例ⅠB2~ⅡB期局部晚期宫颈癌患者的临床资料,根据化疗的途径不同分为两组,静脉化疗组和超选择子宫动脉灌注化疗组(以下简称静脉组和动脉组),其中静脉组68例,动脉组74例,化疗结束后2周左右,结合妇科检查、影像学检查,进行疗效评价。结果化疗总有效率67.6%,其中静脉组64.7%,动脉组70.3%,两组比较,差异无统计学意义(P>0.05)。两组宫旁改善情况比较差异有统计学意义(P<0.05),表明超选择动脉灌注化疗较静脉能更好的改善宫旁条件;动脉化疗毒副反应较静脉少,但静脉组恢复时间较长。术后病理组织情况两组比较均无统计学意义(P>0.05)。结论静脉化疗和超选择子宫动脉灌注化疗均为ⅠB2~ⅡB期局部晚期子宫颈癌新辅助化疗的有效途径,在临床治疗中应根据患者的具体情况选择合适的化疗途径,以得到更好的治疗效果。
Objective To compare the clinical effects of two different routes of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer ⅠB2 ~ ⅡB in order to better guide the clinical. Methods The clinical data of 142 patients with stage ⅠB2 ~ ⅡB advanced cervical cancer treated by Affiliated Tumor Hospital of Xinjiang Medical University from February 2008 to December 2009 were divided into two groups according to the route of chemotherapy: intravenous chemotherapy and superselective Uterine arterial infusion chemotherapy group (hereinafter referred to as vein group and artery group), of which 68 cases of venous, arterial 74 cases, 2 weeks after the end of chemotherapy, combined with gynecological examination, imaging studies, evaluation of the effect. Results The total effective rate of chemotherapy was 67.6%, 64.7% in venous group and 70.3% in arterial group. There was no significant difference between the two groups (P> 0.05). There was significant difference between the two groups (P <0.05), indicating that superselective arterial infusion chemotherapy can improve uterine paralysis better than intravenous injection. Arteroxic chemotherapy has fewer side effects than intravenous injection, but recovery time of intravenous injection long. Postoperative pathological conditions were no significant difference between the two groups (P> 0.05). Conclusions Both intravenous chemotherapy and superselective uterine arterial infusion chemotherapy are effective ways for neoadjuvant chemotherapy of stage ⅠB2 ~ ⅡB advanced cervical cancer. In the clinical treatment, appropriate chemotherapy should be selected according to the specific conditions of the patients so as to obtain better treatment effect.