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目的探讨妊娠高血压的发生发展与全血微量元素含量的关系,为妊娠期高血压的预防及治疗提供理论依据。方法按妊娠期高血压疾病诊断标准将入选的78例晚孕孕妇分为妊娠期高血压、子痫前期轻度、子痫前期重度3个组,40例正常健康晚孕孕妇为对照组;采用火焰原子吸收光谱法分别测定患病组和对照组孕妇全血微量元素(铜、锌、钙、镁、铁)浓度水平,对数据统计处理并进行对照研究。结果患病各组与对照组比较微量元素铜、钙、镁含量无显著性差异(P>0.05);微量元素锌含量在正常对照组、妊娠高血压组、子痫前期轻度组、子痫前期重度组之间依次递减,妊娠高血压组与对照组比较无显著性差异(P>0.05),子痫前期轻、重度组锌元素含量显著低于对照组,差异有统计学意义(P<0.05),子痫前期轻、重度组锌元素含量显著低于妊娠高血压组,差异有统计学意义(P<0.05),子痫前期重度组锌元素含量显著低于子痫前期轻度组,差异有统计学意义(P<0.05);微量元素铁含量在正常对照组、妊娠高血压组、子痫前期轻度组、子痫前期重度组之间依次递增,妊娠高血压组与对照组比较无显著性差异(P>0.05),子痫前期轻、重度组铁元素含量显著高于对照组,差异有统计学意义(P<0.05),子痫前期轻、重度组铁元素含量显著高于妊娠高血压组,差异有统计学意义(P<0.05),子痫前期重度组铁元素含量显著高于子痫前期轻度组,差异有统计学意义(P<0.05)。结论妊娠高血压是孕期常见合并症,要加强妊高征孕妇微量元素的均衡摄入,确保母婴健康。
Objective To investigate the relationship between the occurrence and development of pregnancy-induced hypertension and the content of trace elements in whole blood and to provide a theoretical basis for the prevention and treatment of hypertension during pregnancy. Methods According to the diagnostic criteria of pregnancy-induced hypertension, 78 pregnant women were divided into three groups: pregnancy-induced hypertension, mild preeclampsia, severe preeclampsia and 40 normal pregnant women. The concentration of trace elements (copper, zinc, calcium, magnesium, iron) in whole blood of the diseased group and the control group were determined by flame atomic absorption spectrometry. The data were statistically analyzed and compared. Results Compared with the control group, there was no significant difference in the content of trace elements copper, calcium and magnesium in each group (P> 0.05). The contents of trace element zinc in normal control group, gestational hypertension group, mild preeclampsia group, eclampsia There was no significant difference between the control group and the pregnancy-induced hypertension group (P> 0.05). The levels of zinc in the mild and severe preeclampsia group were significantly lower than those in the control group (P < 0.05). The content of zinc in mild and severe preeclampsia group was significantly lower than that in gestational hypertension group (P <0.05), the content of zinc in severe preeclampsia group was significantly lower than that in mild preeclampsia group The difference was statistically significant (P <0.05); trace elements iron content in the normal control group, gestational hypertension group, mild preeclampsia group, preeclampsia severe group increased in order, pregnancy-induced hypertension group compared with the control group (P> 0.05). The content of iron in mild and severe preeclampsia group was significantly higher than that in control group (P <0.05), and the content of iron in light and severe preeclampsia group was significantly higher than that in control group Pregnancy hypertension group, the difference was statistically significant (P <0.05), preeclampsia Iron content in the degree group was significantly higher than that in the mild preeclampsia group, the difference was statistically significant (P <0.05). Conclusion Pregnancy-induced hypertension is a common complication during pregnancy. It is necessary to strengthen the balanced intake of trace elements in pregnant women with PIH and ensure the health of mother and child.