作者观察了儿童中枢神经系统白血病(CNS-L)患者脑脊液(csf)中肿瘤坏死因子α(TNF-α)、白细胞介素-1β(IL-1β)及干扰素γ(WN-γ)的变化。23例年龄≤15岁的急性白血病患者被分为三组:①有明确的CNS-L(n=8),②CNS-L 缓解期患者(n=5),③未发现CNS-L 者(n=10)。所有患者在测定TNFα、IL-1β及IFNγ的同时测定csf 中白血病细胞数、蛋白质 The authors observed changes in tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interferon γ (WN-γ) in cerebrospinal fluid (csf) in children with central nervous system leukemia (CNS-L). . Twenty-three patients with acute leukemia aged ≤ 15 years old were divided into three groups: 1 There were definite CNS-L (n=8), 2 CNS-L remission patients (n=5), 3 no CNS-L were found (n =10). Simultaneous determination of leukemia cell number and protein in csf in all patients while measuring TNFα, IL-1β and IFNγ