论文部分内容阅读
目的探讨临床常见耐药菌对替加环素产生耐药的机制,对相关研究进展进行综述。方法综述了近年来国内外相关报道,根据细菌产生耐药的机制进行分类阐述,并对替加环素耐药菌的流行情况进行分析。结果细菌对替加环素产生耐药的机制主要与主动外排系统有关,另外还包括药物作用靶位的改变、耐药酶的产生2个方面。在主动外排机制中,RND家族外排泵起着关键作用。替加环素耐药菌在许多国家已经成为临床抗感染难题。结论替加环素耐药机制还需要进一步研究,从而指导临床合理使用替加环素。
Objective To investigate the mechanisms of drug resistance of common drug-resistant bacteria to tigecycline and to review the related research progress. Methods The related reports at home and abroad in recent years were reviewed, classified according to the mechanism of bacterial resistance, and the prevalence of tigecycline - resistant bacteria was analyzed. Results The mechanism of bacterial resistance to Tigecycline was mainly related to the active efflux system. In addition, it also included the change of the target of drug action and the generation of resistant enzyme. In the active efflux mechanism, the RND family efflux pump plays a key role. Tigecyclovir has become a clinical anti-infective problem in many countries. Conclusion The mechanism of tigecycline resistance needs further study to guide the clinical use of tigecycline.