第10号染色体同源丢失性磷酸酶张力蛋白基因(Phosphatase and tension homologue deleted on chromosome ten,PTEN)作为一个肿瘤抑制基因,其编码的蛋白具有双重磷酸酶活性,在细胞的生长、凋亡、分化、粘附、迁移等许多生理、病理过程中发挥重要调控作用。研究表明,PTEN基因不仅参与细胞周期调控,而且调控细胞的正常生长与发育,具有广泛的生物学功能。目前,发现PTEN在皮 As a tumor suppressor gene, PTEN gene has the dual phosphatase activity in the process of cell growth, apoptosis and differentiation , Adhesion, migration and many other physiological and pathological processes play an important regulatory role. Studies have shown that PTEN gene not only involved in cell cycle regulation, but also regulate the normal cell growth and development, has a wide range of biological functions. At present, PTEN is found in the skin